Saturday, 02 April 2016 10:47

Anticoagulation news items. Weeks commencing 29th March 2016

Effect of prior clopidogrel use on outcomes in medically managed acute coronary syndrome patients


Compared with medically managed patients newly started on clopidogrel (CP) in TRILOGY ACS trial, patients previously on CP had a higher risk of CV events. There were no differences in outcomes as stratified by prior CP use by randomised treatment assignment (prasugrel or CP).


Duration of Dual Antiplatelet Therapy: A Systematic Review for the 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease


Review of 11 RCTs (n=33,051 who received predominantly newer-generation drug eluting stents) found moderately strong evidence that prolonged dual antiplatelet therapy entails a trade-off between reductions in stent thrombosis and MI and increases in major haemorrhage.



The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: