Sunday, 24 April 2016 18:47

Anticoagulation news items. Weeks commencing 18th April 2016

Pre-treatment with P2Y12 inhibitors in ACS patients: who, when, why, and which agent?

European Heart Journal

This review evaluates the available evidence on the value of pre-treatment with oral and intravenous P2Y12 inhibitors (clopidogrel, ticagrelor, prasugrel, and cangrelor) that can be administered to patients in whom coronary angiography followed by a possible PCI is planned.


Endovascular treatment versus medical care alone for ischaemic stroke: systematic review and meta-analysis

British Medical Journal

This review (10 RCTs) shows that in selected patients, endovascular treatment given within 6-8hrs after ischaemic stroke involving large vessels leads to improved functional outcome at 90 days without increased mortality vs medical care alone.


Risk of Symptomatic Intracerebral Hemorrhage After Intravenous Thrombolysis in Patients With Acute Ischemic Stroke and High Cerebral Microbleed Burden: A Meta-analysis

JAMA Neurology

This meta-analysis (9 studies; 2479 patients) shows that high cerebral microbleed (CMB) burden on pretreatment MRI is independently associated with symptomatic intracerebral haemorrhage in patients with acute ischaemic stroke treated with iv thrombolysis.



The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: