Saturday, 27 May 2017 18:52

Anticoagulation news items. Week commencing 22nd May 2017

Clopidogrel reloading for patients with acute myocardial infarction already on clopidogrel therapy

European Heart Journal

This analysis of patients admitted to hospital with myocardial infarction who were on clopidogrel pre-admission (n=12,366 STEMI and 39,158 NSTEMI) found that reloading (75.8% STEMI and 25.9% NSTEMI) was not associated with increased risk of major bleeding or mortality.

 

Specific antidotes for bleeding associated with direct oral anticoagulants

British Medical Journal

This BMJ 'Practice' article discusses strategies to reverse anticoagulant activity of direct oral anticoagulants (DOACs), focusing on newer specific antidotes (idarucizumab [the only one currently licensed]; andexanet alfa, and ciraparantag).

 

 

The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:

http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services