Management of superficial venous thrombosis of the leg
Drug and Therapeutics Bulletin
Review notes lack of consensus on best treatment but oral NSAIDs and compression stockings are used to provide symptomatic relief for pain and swelling. Guidelines suggest that fondaparinux or a low molecular weight heparin are options for some high risk patients.
The Lancet Haematology
RCT (n=100, Austria) was terminated early for futility and safety reasons because compared to patients on coagulation factor concentrates, a higher proportion of patients receiving fresh frozen plasma required rescue therapy (52 vs. 4%) and massive transfusion (30 vs. 12%).
European Heart Journal
Paper notes that while available clinical data for specific antidotes of NOACs are limited, it is very likely these agents will successfully reverse.
Thrombophilia Testing in Provoked Venous Thromboembolism: A Teachable Moment
JAMA Internal Medicine
This Teachable Moment looks at the value of testing for inherited thrombophilia in patients with provoked venous thrombophilia.
The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:
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