Friday, 22 December 2017 18:45

Anticoagulation news items. Week commencing 18th December 2017

Characteristics of patients with atrial fibrillation prescribed antiplatelet monotherapy compared with those on anticoagulants: insights from the GARFIELD-AF registry

European Heart Journal

In GARFIELD-AF registry (n=51,270 from 35 countries), ~ half of reasons why anticoagulants are withheld in eligible patients are physicians' decisions, which range from perceived low stroke risk, risk of bleeding, falling, or fear of low compliance to guideline recommendations.


Revised SPCs: Advate (human coagulation factor VIII) injection- Baxject II-all presentations

electronic Medicines compendium

Scientific information on inhibitors have been updated in the SPCs.


Desmopressin use for minimising perioperative blood transfusion

Cochrane Database of Systematic Reviews

Review (65 RCTs; n=3874) found that differences in transfusion and blood loss when people were treated with desmopressin or placebo were small and unlikely to be of clinical importance.


Rituximab for treating inhibitors in people with inherited severe hemophilia

Cochrane Database of Systematic Reviews

No RCTs were identified on the efficacy and safety of rituximab for treating inhibitors in people with hemophilia. The evidence base is limited to case reports and case series.


Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial.

Academic Emergency Medicine

RCT (N=124) reported that within 10 minutes of treatment, bleeding was stopped in 73% of the patients in the tranexamic acid group, compared with 29% in the anterior nasal packing group (difference = 44%, 95% CI, 26% to 57%; p < 0.001).



The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: