Friday, 26 January 2018 19:00

Anticoagulation news items. Week commencing 22nd January 2018

Revised SPC: Tildiem (diltiazem) – all formulations

electronic Medicines compendium

Following a recent update highlighting that diltiazem has been shown to inhibit platelet aggregation, the SPC now advises that concomitant administration with acetylsalicylates (e.g. aspirin) should be undertaken with caution.


Reasons for and consequences of oral anticoagulant underuse in atrial fibrillation with heart failure


Analysis of data from Swedish Heart Failure Registry noted of 21 865 patients, only 12 659 (58%) received oral anticoagulants (OACs). Reasons for not receiving OACs were not based on rational grounds and bleeding risk inappropriately affected decision-making more than stroke risk.


Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality

Journal of the American Medical Association

Retrospective cohort study (n=141,311 with intracerebral haemorrhage) found prior use of NOACs/warfarin was linked to higher in-hospital mortality (IHM) vs. no oral anticoagulants. Prior use of NOACs (vs. warfarin) was linked to lower risk of IHM (OR, 0.75; 97.5% CI, 0.69-0.81).



The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: