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Friday, 03 September 2021 08:49

Anticoagulation news items. Weeks commencing 30th August 2021

Thrombolytic therapy for pulmonary embolism

Cochrane Database of Systematic Reviews
Review (21 RCTs [3 new]; n=2401) found low‐certainty evidence suggesting thrombolytics may reduce death following acute PE compared with heparin and may be helpful in reducing the recurrence of pulmonary emboli, but may cause more major and minor haemorrhagic events.


Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

New England Journal of Medicine
In people at high risk of bleeding after implantation of drug-eluting stent (n=4434), 1 month of dual antiplatelet therapy was non-inferior to continuation for ≥2 additional months with regard to occurrence of net adverse clinical events and major adverse cardiac/cerebral events.


Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR

New England Journal of Medicine
In this study (n=1426), edoxaban was non-inferior to vitamin K antagonists in terms of the primary composite endpoint (death, MI, ischaemic stroke, systemic thromboembolism, valve thrombosis, major bleeding) in people with AF after successful TAVR (HR 1.05; 95% 0.85-1.31; p=0.01).


2021 European Society of Cardiology/European Association for Cardio-Thoracic Surgery Guidelines for the management of valvular heart disease

European Heart Journal
This updated guideline considers new evidence in this area, leading to a number of new recommendations, including use of anti-thrombotic therapies in patients with surgical or transcatheter bioprostheses for bridging during perioperative periods and over the long term.



The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: