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Thursday, 21 August 2014 12:27

Anticoagulation news items. Weeks commencing 4th and 11th August 2014

What is the evidence for the use of Low Molecular Weight Heparins for the prophylaxis of travel-related thrombosis?


This Medicines Q&A evaluates the evidence for using low molecular weight heparins for the prevention of travel-related venous thromboembolism


Update on Chronic Thromboembolic Pulmonary Hypertension

This review on thromboembolic pulmonary hypertension covers epidemiology and definition, mechanisms of disease, clinical characteristics, diagnostic procedures, and treatment.


MHRA launches learning module on oral anticoagulants

Medicines and Healthcare products Regulatory Agency
The MHRA has launched an online learning module for healthcare professionals outlining the key risks of oral anticoagulants. The module includes a description of important adverse effects, factors that increase their risk, how risk can be reduced, and specific treatments.


Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

The Lancet
This meta-analysis of individual patient data from 9 RCTs of alteplase for acute ischaemic stroke found that it improved the odds of a good stroke outcome versus control when given within 4.5 hours, with proportional treatment benefits similar regardless of age or stroke severity.


Frequent and possibly inappropriate use of combination therapy with an oral anticoagulant and antiplatelet agents in patients with atrial fibrillation in Europe

This analysis of European registry data found that 10.9% of patients with AF were treated with a combination of oral anticoagulant and one or two antiplatelets. The majority of those on dual (95%) or triple (64%) combination therapy did not have an accepted indication.


Perioperative Atrial Fibrillation and the Long-term Risk of Ischemic Stroke

Journal of the American Medical Association
Among patients hospitalised for surgery, perioperative AF was linked to increased long-term risk of ischaemic stroke. More studies are needed to better delineate the risk and determine optimal antithrombotic strategies in such patients with other risk factors for stroke.




The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: