FDA grants priority review to Biologics License Application for idarucizumab
Biospace Inc.
Idarucizumab, a humanised antibody fragment, is being investigated to specifically reverse the anticoagulant effect of dabigatran in patients needing emergency intervention or experiencing an uncontrolled or life-threatening bleeding event.
Hospital Pharmacy
Retrospective claims analysis (n=134, rivaroxaban [RV], n=536 historical LMWH/warfarin-treated patients) found availability of RV reduced
hospitalisation rate in patients with DVT treated with RV vs. what it would have been if only LMWH/warfarin were available (60% vs. 82%).
National Institute for Health Research
No new trials were located; the review was therefore largely based on the evidence available for TA182 (TRITON-TIMI 38 trial). A new economic model confirmed prasugrel is likely to be a cost-effective treatment option when compared with clopidogrel for all subgroups considered.
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