Thromboembolic Complications and Prophylaxis Patterns in Colorectal Surgery
JAMA Surgery
US study of 16,120 patients who had undergone colorectal surgery found venous thromboembolism rates are low and largely unchanged despite increases in peri-and postoperative prophylaxis. With ~40% events occurring after discharge, this represents an area for quality improvement.
Cochrane Database of Systematic Reviews
There is low quality evidence that ursodeoxycholic acid may reduce incidence of disease, all-cause mortality and mortality in HSCT recipients. There is insufficient evidence to support use of heparin, LMWH, defibrotide, glutamine, FFP, antithrombin III, and PGE1.
Revised SPC: Plavix (clopidogrel) 75mg tablets
electronic Medicines Compendium
In section 4.5 (interactions), the list of CYP2C19 inhibitors has been amended so that it now only lists examples of strong or moderate inhibitors (ciprofloxacin, cimetidine, oxcarbazepine and chloramphenicol have been removed).
The Lancet
In a proof-of-concept study in healthy volunteers, idarucizumab (monoclonal antibody fragment that binds dabigatran) was found to immediately and completely reverse dabigatran-induced anticoagulation in a dose-dependent manner.
British Medical Journal
Some doctors have been questioning efficacy and safety of alteplase —and methodology of some of trials assessing it. Unpublished data are still missing on certain endpoints including early mortality. The MHRA is due to publish a review on alteplase towards end of 2015.
The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:
http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services
