Monday, 27 January 2014 00:00

Anticoagulation news items. Week commencing 27th January 2014

 

Antiplatelet Therapy for Stable Coronary Artery Disease in Atrial Fibrillation Patients on Oral Anticoagulant: A Nationwide Cohort Study

This study of 8,700 patients with AF and stable CAD (>12 months from an acute event) found combined vitamin K antagonist (VKA) plus antiplatelet was not associated with a reduced risk of MI/coronary death or thromboembolism vs. VKA monotherapy, but bleeding risk was increased.

http://circ.ahajournals.org/content/early/2014/01/27/CIRCULATIONAHA.113.004834.abstract

 

Risk of drug-induced liver injury with the new oral anticoagulants: systematic review and meta-analysis

This analysis of 29 RCTs (n=152,116, mean follow-up 16 months) found that NOACs were not linked to increased risk of drug-induced liver injury (RR 0.90, 95% CI, 0.72 to 1.13, I2=0%). Similar results were obtained for individual NOACs.

http://heart.bmj.com/content/early/2014/01/29/heartjnl-2013-305288.abstract

 

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