Saturday, 07 November 2015 10:39

Anticoagulation news items. Weeks commencing 2nd November 2015

Treatment strategies for coronary in-stent restenosis: systematic review and hierarchical Bayesian network meta-analysis of 24 randomised trials and 4880 patients

British Medical Journal

Compared with plain balloons, bare metal stents, brachytherapy, rotational atherectomy, and cutting balloons, drug coated balloons and drug eluting stents were linked to reduced risk of target lesion revascularisation, major adverse cardiac events, and reduced late lumen loss.

 

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial

The Lancet

Trial was terminated early after enrolment of 3232 patients due to severe allergic reactions with reversible factor IXa inhibitor REG1, as currently formulated. Although statistical power was limited, there was no evidence REG1 reduced ischaemic events/bleeding vs. bivalirudin.

 

 

The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:
http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services