Items filtered by date: June 2021

The association between increasing oral anticoagulant prescribing and atrial fibrillation related stroke in Ireland

British Journal of Clinical Pharmacology
Registry study of data between 2005 and 2018 found an increase in the use of oral anticoagulants of 94%, mainly fuelled by use of DOACs. Ischaemic stroke rates did not reduce, however the percentage of patients with a stroke diagnosed with AF decreased between 2013 and 2018.

 

P2Y12 inhibitor monotherapy or dual antiplatelet therapy after coronary revascularisation: individual patient level meta-analysis of randomised controlled trials

British Medical Journal
Meta-analysis (6 trials;n=24 096) found P2Y12 inhibitor monotherapy linked to similar risk of death, MI, or stroke, with evidence this may be modified by sex & lower bleeding risk vs. dual antiplatelet therapy (primary outcome occurred in 2.94 vs. 3.36%;HR 0.90, 95% CI 0.77-1.08).

 

 

The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:

http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services

Published in News

Updated COVID-19 vaccination guidance: blood clotting information for healthcare professionals

Public Health England
This guidance has been updated to include antiphospholipid syndrome, interchangeability of COVID-19 vaccines, samples required for whole genome sequencing and the latest MHRA data.

 

Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial

British Medical Journal
RCT (n=1471, Canada & India) found that in patients with AF or mechanical heart valves who had warfarin interrupted for a procedure, no significant benefit was found for postop dalteparin bridging to prevent major thromboembolism (occurred in 1.0% vs. 1.2% placebo within 90 days).

 

 

The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:

http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services

Published in News