Revised SPC: TachoSil (human fibrinogen and thrombin) sealant matrix

electronic Medicines Compendium

SPC advises that to prevent development of tissue adhesions (AHs) at undesired sites, tissue areas outside desired application area should be adequately cleansed before administration of TachoSil. AHs to GI tissues have been reported with use during abdo surgery close to bowel.

Oral direct factor Xa inhibitor versus enoxaparin for thromboprophylaxis after hip or knee arthroplasty: Systemic review, traditional meta-analysis, dose–response meta-analysis and network meta-analysis

Thrombosis Reasearch

Review of 20 trials (n= 38,507) found that direct oral factor Xa inhibitors are more effective than enoxaparin in preventing venous thromboembolism after total hip or knee replacement. Their anticoagulant effect was not necessarily compromised with a higher bleeding risk.

Stent Retrievers for the Treatment of Acute Ischemic Stroke A Systematic Review and Meta-analysis of Randomized Clinical Trials

JAMA Neurology

Patients randomised to stent-retriever therapy (used for mechanical thrombectomy) with recombinant tissue plasminogen activator (rtPA) had improved rates of functional independence at 90 days v those on rtPA alone (RR 1.72; 95% CI, 1.48-1.99).

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