Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation
Heart
Biomarker substudy (n=4850) suggests in situation without acute increased coagulation activity (e.g AF), apixaban reduces coagulation markers D-dimer and fragment 1+2 to lower degree vs. warfarin, which seems enough to protect against stroke without increasing bleeding risk.
Aspirin-Exacerbated Respiratory Disease
New England Journal of Medicine
Review covers atopic diseases, COX-1 inhibitor reactions, medical history, prevalence, non-aspirin-exacerbated respiratory disease, NSAID hypersensitivity, pathological and pharmacopathological features, medical/surgical treatment, aspirin (AS) desensitisation and AS treatment.
Anticoagulation for people with cancer and central venous catheters
Cochrane Database of Systematic Reviews
This review (13 RCTs; n=3420) found moderate-certainty evidence that LMWH reduces catheter‐related venous thromboembolism (CR-VTE); evidence was inconclusive for LMWH effects on mortality and effects of vitamin K antagonists (VKA) on mortality or CR-VTE, and for LMWH versus VKA.
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