European Heart Journal
Analysis (n=2198) found death and major bleeding occurred in 5.1% on bivalirudin, 7.6% on heparin plus routine GPI (HR 0.67; 95% CI 0.46–0.97, p=0.034), and 9.8% on heparins plus bailout GPI (0.52; 0.35–0.75, p=0.006). Rates of stent thrombosis were higher with bivalirudin.
Posterior circulation ischaemic stroke
British Medical Journal
This review aims to demonstrate the importance and challenges of recognising and treating posterior circulation stroke, which accounts for 20-25% of ischaemic strokes. It discusses causes, clinical symptoms and signs, and its diagnosis and management.
Management of Anticoagulation Around Pacemaker and Defibrillator Surgery
Circulation
This Clinician Update discusses the management of warfarin and the new oral anticoagulants (NOACs) around the time of surgery in patients having defibrillator and pacemaker surgery, illustrated with two case examples, for which recommendations on suggested management are given.
European Medicines Agency
The European CHMP has recommended approval of simoctogog alfa (Nuwiq) for the treatment and prophylaxis of bleeding in paediatric and adult patients with haemophilia A (congenital factor VIII deficiency).
The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:
http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services
