Saturday, 31 May 2014 08:02

Anticoagulation news items. Week commencing 26th May 2014

Delay in Filling First Clopidogrel Prescription After Coronary Stenting Is Associated With an Increased Risk of Death and Myocardial Infarction

Journal of the American Heart Association
Study of 15 629 patients treated with coronary stents found delay >3 days in obtaining 1st script for clopidogrel is predictive of mortality and recurrent MI (DES: HR, 2.4; 95% CI, 1.7 to 3.4; and 2.0; 1.5 to 2.7, and BMS: 2.2; 1.9 to 2.6; and 1.8; 1.5 to 2.1, respectively).


Boehringer to settle lawsuits against dabigatran (Pradaxa) in US

Boehringer Ingelheim is to pay about $650 million to settle U.S. lawsuits that claimed dabigatran had caused severe and fatal bleeding in patients. The claimants had accused the company of not issuing sufficient warnings of the risks associated with this drug.


Vitamin K Antagonists and Risk of Subdural Hematoma: Meta-Analysis of Randomized Clinical Trials

This meta-analysis (19 RCTs; n=92,156) found the risk of subdural haematoma associated with vitamin K antagonists to be higher than the risk with antiplatelets (odds ratio 3.0; 95% CI 1.5–6.1), factor Xa inhibitors (2.9; 2.1–4.1) and direct thrombin inhibitors (1.8; 1.2–2.7).



The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: