Friday, 18 June 2021 09:50

Anticoagulation news items. Weeks commencing 14th June 2021

The association between increasing oral anticoagulant prescribing and atrial fibrillation related stroke in Ireland

British Journal of Clinical Pharmacology
Registry study of data between 2005 and 2018 found an increase in the use of oral anticoagulants of 94%, mainly fuelled by use of DOACs. Ischaemic stroke rates did not reduce, however the percentage of patients with a stroke diagnosed with AF decreased between 2013 and 2018.


P2Y12 inhibitor monotherapy or dual antiplatelet therapy after coronary revascularisation: individual patient level meta-analysis of randomised controlled trials

British Medical Journal
Meta-analysis (6 trials;n=24 096) found P2Y12 inhibitor monotherapy linked to similar risk of death, MI, or stroke, with evidence this may be modified by sex & lower bleeding risk vs. dual antiplatelet therapy (primary outcome occurred in 2.94 vs. 3.36%;HR 0.90, 95% CI 0.77-1.08).



The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: