Circulation
This study noted that bridging anticoagulation is used in a-quarter of anticoagulation interruptions and is linked to higher risk for bleeding (5.0 vs. 1.3%, OR 3.84, p<0.0001) and adverse events (13 vs. 6.3%; OR 1.94, p=0.0001) vs. non-bridging.
Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis
New England Journal of Medicine
RCT in 300 patients found FXI-ASO was non-inferior (200mg OD) or superior (300mg OD) to enoxaparin 40mg OD daily in prevention of VTE in patients undergoing total knee arthroplasty (VTE in 27%, 4% and 30%; and bleeding in 3%, 3%, and 8%; respectively).
Biospace Inc.
Administration of idarucizumab in these groups (n=46) resulted in immediate, complete and sustained reversal of the anticoagulation effects of dabigatran. Anticoagulation was restored when volunteers were re-dosed with dabigatran 24 hours after idarucizumab was administered.
The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:
http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services