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Saturday, 13 December 2014 11:59

Anticoagulation news items. Week commencing 1st and 8th December 2014

Use and Outcomes Associated with Bridging During Anticoagulation Interruptions in Patients with Atrial Fibrillation: Findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)

This study noted that bridging anticoagulation is used in a-quarter of anticoagulation interruptions and is linked to higher risk for bleeding (5.0 vs. 1.3%, OR 3.84, p<0.0001) and adverse events (13 vs. 6.3%; OR 1.94, p=0.0001) vs. non-bridging.


Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

New England Journal of Medicine

RCT in 300 patients found FXI-ASO was non-inferior (200mg OD) or superior (300mg OD) to enoxaparin 40mg OD daily in prevention of VTE in patients undergoing total knee arthroplasty (VTE in 27%, 4% and 30%; and bleeding in 3%, 3%, and 8%; respectively).


Conference report: Phase I study reports idarucizumab reverses anticoagulant effects of dabigatran in middle-aged, elderly and renally impaired volunteers

Biospace Inc.

Administration of idarucizumab in these groups (n=46) resulted in immediate, complete and sustained reversal of the anticoagulation effects of dabigatran. Anticoagulation was restored when volunteers were re-dosed with dabigatran 24 hours after idarucizumab was administered.




The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at: