Items filtered by date: June 2022


Direct oral anticoagulants in the treatment and long-term prevention of venous thrombo-embolism 

This article reviews direct oral anticoagulants (e.g. apixaban, dabigatran and rivaroxaban) under the following topic headings: Acute and long-term treatment of VTE; Extended treatment of VTE; Lessons from the developmentprogrammes for these drugs; and practical considerations.


Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack

PPAR- agonists were found to reduce recurrent stroke and total events of CV death, non-fatal MI or non-fatal stroke, and improve insulin sensitivity and stabilisation of carotid plaques, but findings should be interpreted cautiously due to small number and quality of the studies.


Point-of-care coagulometers (the CoaguChek XS system and the INRatio2 PT/INR monitor) in people on long-term vitamin K
antagonist therapy who have atrial fibrillation or heart valve disease: diagnostics consultation document

Draft guidance from NICE's Diagnostics Assessment Programme on two technologies for self-monitoring the clotting of blood in people on long term anticoagulation therapy has been issued for public consultation.


Aspirin versus vitamin K antagonist treatment guided by transoesophageal echocardiography in patients with atrial fibrillation: a pilot study

The results of this study (n=238) suggest that transoesophageal echocardiography (TEE) may help to refine stroke risk and guide antithrombotic treatment choice (VKA or aspirin) in patients with paroxysmal atrial fibrillation. Further research is however required.


Ultrasound-assisted thrombolysis for acute pulmonary embolism: a systematic review

The authors of this review discuss catheter-based revascularisation for PE and ultrasound-assisted thrombolysis and present and discuss the results of seven studies (n=197) of ultrasound-assisted catheter-directed thrombolysis (CDT) for PE (only one small RCT).


Media hype blood clot risk of birth control pills

This 'Behind the Headlines' assessment discusses the risk of venous thromboembolism associated with use of combined oral contraceptives
(following the recent European review) and comments that the UK media overhyped the potential risk in their reporting.


The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service.
Further details on this service can be found at:


Published in News

The findings of the King's Thrombosis Centre's population pharmacokinetic modelling study of enoxaparin in pregnancy was reviewed by Nature Reviews Cardiology. The review assessed the significance of the findings and includes a commentary from Professor Jeff Ginsberg from McMaster University, Hamilton, ON, Canada.

Access the article here.

Published in News

King's Thrombosis Centre have published an article in CIRCULATION describing the development of a robust pharmacokinetic model of enoxaparin in pregnant women. At each monthly clinic visit, participants provided blood samples for assessment of anti-factor Xa activity in plasma at three time points—trough (the lowest concentration before the next dose), and 1 h and 3 h after enoxaparin injection. One hundred and twenty three patients contributed 795 anti-Xa activities for the modelling. Both enoxaparin clearance and volume of distribution were increased during pregnancy and the findings provide evidence for prescribing once daily enoxaparin for the treatment of antenatal VTE. The conclusion is that national and international guideline recommendations for enoxaparin dosing in pregnancy should be re-considered.


Access the article here

Published in News

King's Thrombosis Centre have published an article in CHEST evaluating the impact of compulsory VTE risk assessment on the incidence of hospital-associated VTE. A significant reduction in the incidence of HAT was observed following sustained achievement of 90% risk assessment (RR 0.88, 95% CI 0.74 - 0.98; P=0.014). The article entitled "Comprehensive venous thromboembolism prevention programme incorporating mandatory risk assessment reduces the incidence of hospital-associated thrombosis" can be accessed here

Published in News

King's Thrombosis Centre have published an article in the British Journal of Haematology evaluating the early predictors of post-thrombotic syndrome. The article entitled "Presenting D-dimer and early symptom severity are independent predictors for post-thrombotic syndrome following a first deep vein thrombosis" can be accessed here.

Published in News

The project is being led by Dr Jig Patel, Senior Lecturer, Institute of Pharmaceutical Science at King's College London.

Published in News
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