Research

Research

We are an experienced multi-disciplinary clinical academic team, conducting translational research in the field of thrombosis and haemostasis. Our group’s research is focused on 4 key themes:

Venous Thromboembolism

Research completed under this theme include:

King's Thrombosis Centre - Research page - Scientist looking through microscope

Women’s health

Research completed under this theme include:

  • Pharmacokinetics of enoxaparin during the antenatal period
  • Demonstrating that women with unexplained recurrent pregnancy loss do not have evidence of an underlying prothrombotic state
  • Exploring the prothrombotic phenotype of mode of delivery and its impact on VTE risk
  • Understanding women’s experiences and adherence to LMWH during pregnancy and the postnatal period
  • Reporting an increased risk of heavy menstrual bleeding with rivaroxaban
  • Exploring the distribution of DOACs into breast milk
  • The impact of anticoagulation therapy on women’s menstrual cycles and their quality of life – the PERIOD study

Currently the following studies are being undertaken under this theme:

  • The New Horizons Clinical Trial, which is evaluating whether edoxaban or rivaroxaban can be prescribed to breastfeeding mothers.

  • A study investigating whether uterine fibroids cause changes in the blood that increase the risk of developing blood clots.

Acquired bleeding states

Research completed under this theme include:

Currently the following study is being undertaken under this theme:
Funded by the MRC/NIHR, the EMErALD study is assessing whether novel blood tests such as thromboelastography, thrombin generation, clot lysis assays and neutrophil extracellular traps can better measure haemostasis in patients with liver disease admitted to hospital, and thereby reduce the use of transfusion.

The safe and effective use of anticoagulants

Research completed under this theme include:

Currently the following study is being undertaken under this theme:
Funded by a NIHR PCAF, developing a pharmacokinetic model for edoxaban from a heterogeneous anticoagulation clinic population

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