The First Registry

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Follow-up In Rivaroxaban patients in Setting of Thromboembolism

The aim of the FIRST Registry is to study the incidence of long-term complications (VTE, PTS and CTEPH) for VTE treated with rivaroxaban without bridging heparin (up to 5 years) in routine clinical practice.

Currently, within the UK, patients diagnosed with deep vein thrombosis (DVT) and/or pulmonary embolism (PE) are initiated on a short course of parenteral heparin as bridging therapy overlapped and followed by an oral vitamin K antagonist (VKA). This two-drug approach of VKA with bridging heparin is effective in reducing recurrence but has limitations.

The oral anticoagulant rivaroxaban offers a simple, single-drug approach to the short-term and continued treatment of VTE.

The FIRST Registry will primarily assess long-term outcomes for the treatment with rivaroxaban of acute VTE and its secondary prevention in routine clinical practice. In addition, analysis of these data may contribute to improved risk stratification strategies to identify patients who have the greatest risk of adverse events (bleeding), recurrence and long-term VTE-related morbidity.


largebluebutton Access the FIRST Registry database here



Download supporting documents:    



docxFIRST Registry Case Report Form


docxAdherence Screening








FIRST Registry Results


Thank you to everyone who has participated in the FIRST registry. 


Please find a summary of the results below and links to the journal articles. 



Rivaroxaban in acute venous thromboembolism; UK prescribing experience


UK real-world experience of prescribing rivaroxaban for acute venous thromboembolism in obesity: Results from the FIRST Registry


Adherence to rivaroxaban for the treatment of venous thromboembolism–Results from the FIRST registry


For all queries related to the FIRST Registry please email:

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Chief Investigator:

Professor Roopen Arya

Lead Clinician, Haematological Medicine; Head, Haemostasis & Thrombosis

King's College Hospital NHS Foundation Trust
+44 203 299 1183


Research Fellow: 

Vicky Speed

King's College Hospital NHS Foundation Trust
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.


          Partcipating Centres and Principal Investigators:

King's College Hospital NHS Foundation Trust (PI Professor Roopen Arya)
Basingstoke and Salisbury NHS Foundation Trust (PI Dr Tamara Everington)
Bournemouth Hospitals NHS Foundation Trust (PI Dr Jason Mainwaring)

Basildon and Thurrock University Hospitals NHS Foundation Trust (PI. Dr. T. Koshy)

The Dudley Group NHS Foundation Trust (Dr. Stephen Jenkins)

St. George's Healthcare NHS Foundation Trust (PI Dr James Uprichard)

Hillingdon Hospitals NHS Foundation Trust (PI. Dr. Muhammad Pasha)

United Lincolnshire Hospitals NHS Trust (PI. Dr. Bethan Myers)

Maidstone and Tunbridge Wells NHS Trust (Dr. Clare Wykes)

Newcastle upon Tyne Hospital NHS Foundation Trust (PI. Dr. Tina Biss)

Poole Hospitals NHS Foundation Trust (PI. Dr. Craig Prescott)

Portsmouth Hospitals NHS Trust (PI. Professor Anoop Chauhan)

Queen's Hospital , Romford (PI Dr. Khalid Saja)

Southampton Hospital NHS Foundation Trust (Dr. Rashid Kazmi)

Salisbury NHS Foundation Trust (PI. Dr. Tamara Everington)

Wye Valley NHS Trust (Dr. Lisa Robinson)

University College Hospitals (Dr. Marie Scully)
University Hospitals Leicester (Dr. Bethan Myers)
Lewisham Hospital (Dr. Kumar Thanigaikumar)

The Royal Devon and Exeter NHS Trust (Dr. Andrew Sharp)

Epsom and St. Helier Hospitals (Dr. Sanjay Mutgi)