Research
Research
We are an experienced multi-disciplinary clinical academic team, conducting translational research in the field of thrombosis and haemostasis. Our group’s research is focused on 4 key themes:
Venous Thromboembolism
Research completed under this theme include:
- Understanding specific VTE risk factors, e.g. Ethnicity, HRT, Stroke, Obesity
- Understanding the long-term outcomes of VTE, e.g. the DVT outcomes study
- National VTE prevention work e.g. Mandatory VTE risk assessment
- COVID-19, e.g. COVID-19 and post discharge VTE risk, PE and COVID-19
- The management of VTE with rivaroxaban – the FIRST Registry, which has assessed outcomes, adherence, and the use of rivaroxaban in the obese population
Women’s health
Research completed under this theme include:
- Pharmacokinetics of enoxaparin during the antenatal period
- Demonstrating that women with unexplained recurrent pregnancy loss do not have evidence of an underlying prothrombotic state
- Exploring the prothrombotic phenotype of mode of delivery and its impact on VTE risk
- Understanding women’s experiences and adherence to LMWH during pregnancy and the postnatal period
- Reporting an increased risk of heavy menstrual bleeding with rivaroxaban
- Exploring the distribution of DOACs into breast milk
- The impact of anticoagulation therapy on women’s menstrual cycles and their quality of life – the PERIOD study
Currently the following studies are being undertaken under this theme:
The New Horizons Clinical Trial, which is evaluating whether edoxaban or rivaroxaban can be prescribed to breastfeeding mothers.
- A study investigating whether uterine fibroids cause changes in the blood that increase the risk of developing blood clots.
Acquired bleeding states
Research completed under this theme include:
- Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation
- Whole blood thrombin generation in liver cirrhosis
- The prothrombotic effectof FFP and platelet transfusion in liver disease
Currently the following study is being undertaken under this theme:
Funded by the MRC/NIHR, the EMErALD study is assessing whether novel blood tests such as thromboelastography, thrombin generation, clot lysis assays and neutrophil extracellular traps can better measure haemostasis in patients with liver disease admitted to hospital, and thereby reduce the use of transfusion.
The safe and effective use of anticoagulants
Research completed under this theme include:
- Understanding patients adherence, illness beliefs, experiences and medication beliefs when prescribed warfarin and DOACs
- Use of DOACs in special populations, e.g. patients with HIV and newly diagnosed multiple myeloma
- Sharing experience of how best to manage DOACs during dentoalveolar surgery
- Developing a pharmacokinetic model for rivaroxaban from a heterogenous anticoagulation clinic population
Currently the following study is being undertaken under this theme:
Funded by a NIHR PCAF, developing a pharmacokinetic model for edoxaban from a heterogeneous anticoagulation clinic population